Directions: For all supplements, follow instructions on product labels. For best results, use daily.

Collagen Synthesis™: Mix one unflavored scoop into any beverage or meal once daily. For best results, consume one serving 30 minutes before exercise.

Remodel Clinic™: Take 2 capsules daily with or without food, or as directed by a healthcare professional.  For best results, take Remodel Clinic™ at least one hour before or after using Collagen Synthesis™.  (This ensures the enzymes in Remodel Clinic™ do not prematurely break down the collagen peptides in Collagen Synthesis™ during digestion.)

Joint Clinic™: Follow the TaperSmart™ Dosage schedule to jump-start your recovery. Here's how it works:

• Weeks 1-2: Take 4 capsules with breakfast and 4 capsules with dinner.

  
  

• Weeks 3-4: Take 3 capsules with breakfast and 3 capsules with dinner.

  
  

• Weeks 5-6: Take 2 capsules with breakfast.

For Daily Use: After completing the first 6-week TaperSmart™ cycle, take 4 capsules daily with food*.

*It’s important to take Joint Clinic™ with food to help optimize the absorption of some of its nutrients.

Fortigel^® is a collagen peptide that has been effectively ‘cut’ to match the receptor sites within cartilage tissues. When consumed, it helps stimulate chondrocytes — the cells responsible for cartilage maintenance.⁹

Collagen Synthesis contains 5 grams of Fortigel^®— the clinically supported dosage for supporting cartilage maintenance.

Tendoforte^® has a molecular weight that matches the receptor sites in tendons and ligaments. It helps produce more fibroblasts. These are the cells responsible for synthesizing new collagen and maintaining the structural framework of connective tissue.⁹

Fibroblasts also play a crucial role in the tissue healing process, making Tendoforte^® especially effective at improving the strength and stability of tendons and ligaments.

The clinically supported dosage of Tendoforte^® is 5 grams (taken before exercise).

Supplementing with Vitamin C supports optimal collagen formation and reduces oxidative damage from exercise-induced tissue stress.^{10, 11}

In cases of Vitamin C deficiency, collagen fibers are not able to repair properly and lack adhesion strength. More importantly, your body can’t form or store collagen without Vitamin C present, making it a crucial cofactor in the collagen formation process.

A 2019 pilot study published in the International Journal of Sport Nutrition and Exercise Metabolism showed that taking Vitamin C in conjunction with collagen peptides before training doubled collagen synthesis rates in the exercising joints.¹²

The only problem is Vitamin C can be rough on your stomach when taken before exercise. That’s why we included 120 mg (133% Daily Value) of easily-digested, Buffered Vitamin C in each serving of Collagen Synthesis.

When you take hyaluronic acid in conjunction with collagen peptides, you get a synergistic joint-building response. That’s because hyaluronic acid works with collagen to provide a moisture-rich environment within joint structures. This enables collagen fibers to stretch without breaking, improving their resilience and reducing fiber tears during the critical tissue remodeling phase of tissue recovery.

This is a vital part of the rebuilding process, as fragile new collagen fibers need time to stretch and align properly without breaking down.

Studies show supplementing with hyaluronic acid:

• Provides structural support for collagen-producing fibroblasts

• Improves synovial fluid effusion in joints and reduces joint discomfort

• Improves joint strength (52 mg of hyaluronic acid helped healthy subjects with mild joint discomfort improve their knee strength)

Collagen Synthesis contains 80 mg of hyaluronic acid to bolster the collagen rebuilding process.

Choline-stabilized orthosilicic acid is a highly absorbable form of the mineral silicon. Silicon plays a pivotal role in collagen synthesis within joints, bone mineralization, and overall immune health. Even though silicon is one of the most abundant minerals on the planet, most people don’t get enough.

That’s because it doesn’t accumulate in the body. Multiple studies have shown that silicon supplementation improves joint, bone, and skin health.¹⁷

Studies indicate that combining choline-stabilized orthosilicic acid with collagen peptides may stimulate collagen production and connective tissue repair more than either ingredient would on its own.¹⁸

Because it appears to support tissue remodeling when combined with collagen, we included 10 mg of choline-stabilized orthosilicic acid in every serving of Collagen Synthesis™. This is the most bioavailable form of the mineral and the most targeted method of supporting collagen maintenance, rebuilding, and longevity.

++

As you can see, Collagen Synthesis is much more than just another collagen protein powder. In addition to patented collagen peptides designed to target specific joint structures, we also included key supportive nutrients that further bolster the absorption and utilization process.

So, instead of merely taking undifferentiated collagen protein (and only seeing marginal improvements in joint health and recovery times) — you can give your joints exactly what they need. You won’t find this level of targeted therapeutic nutrition anywhere besides inside Collagen Synthesis.

Fisetin is a natural flavanol found in strawberries and other fruits. It helps maintain joint flexibility and reduce stiffness by supporting the body’s natural repair mechanisms. This includes senescent cell removal and tissue turnover.¹

Research shows fisetin:

• Promotes Joint Comfort and Flexibility. Fisetin supports a healthy inflammatory response to exercise and daily stressors and supports the body’s natural connective tissue remodeling processes.²

  
  

• Supports Healthy Scar Tissue Formation. Its ability to support cellular health and tissue repair mechanisms may help aid the body’s naturally balanced scar tissue formation processes, which are essential for recovery and maintaining mobility.³

  
  

• Provides Antioxidant Protection. Fisetin provides robust antioxidant protection, combating oxidative stress that can lead to cellular damage and contribute to joint discomfort.⁴

Remodel Clinic™ contains 125 mg of fisetin per serving.

Quercetin is a powerful flavonoid found in fruits and vegetables. It has antioxidant properties that help alleviate joint stiffness and discomfort, promote cellular repair, and bolster overall connective tissue health.⁵ High-level athletes use quercetin to help naturally improve endurance and athletic performance by promoting healthy cell turnover and recovery processes.⁶

Research shows quercetin:

• Supports Joint Health and Longevity. Research indicates quercetin can help you maintain an active lifestyle while protecting joints against the wear and tear associated with exercise and regular activity.⁷

  
  

• Assists Healthy Immune Response to Exercise. Quercetin's antioxidant properties may bolster the immune system, aiding post-exercise recovery and reducing the risk of exercise-induced joint stress accumulation.⁸

  
  

• Facilitates Quicker Recovery. Quercetin's ability to decrease oxidative stress after exercise may lead to faster recovery, helping you return to peak performance sooner.⁹

Remodel Clinic™ contains 500 mg of quercetin per serving.

Bromelain is a natural enzyme found in pineapple. It helps break down protein and supports healthy levels of inflammation and swelling.^{10, 11}

Research shows bromelain:

• Promotes Joint Comfort. Bromelain helps maintain joint comfort and mobility by promoting the body's natural recovery processes – including removing dead cells and healthy new cell growth – in response to everyday stress and physical activity.^{12, 13}

  
  

• Supports Digestive Health. Bromelain aids in the breakdown of proteins in the digestive tract, which could help support optimal nutrient absorption and overall gastrointestinal comfort.¹⁴

  
  

• Bolsters Recovery. Bromelain supports the body's recovery process by aiding tissue healing and reducing discomfort associated with physical exertion.^{15, 16}

Remodel Clinic™ contains 200 mg of bromelain (from pineapple) per serving.

Senactiv® is a powerful, science-backed senolytic ingredient that elevates exercise endurance, recovery, and energy by promoting senescent cell removal, as well as new joint and muscle cell turnover.

Research shows Senactiv®:

• Promotes Muscle Cell Regeneration and Recovery. Senactive® reduces markers of joint and muscle stress.^{17, 18}

  
  

• Helps Reduce Damage to Muscle After Exercise. One study found that Senactiv® reduced MDA synthesis stress, a marker of free radical damage, by 44%.¹⁹

  
  

• Supports Elimination of Senescent Cells in Skeletal Muscle. Senactiv® helps generate new muscle cells and clear senescent cells, which supports a more efficient repair and growth process post-exercise.²⁰

Remodel Clinic™ contains 50 mg of Senactiv® per serving.

Vitamin C is essential in supporting healthy tissue formation and recovery, which can help optimize recovery – especially when it comes to joint stress.²¹ PureWay-C^® is a patented form of vitamin C that uses liposomal delivery for optimal absorption.

Research shows PureWay-C^®:

• Promotes Healthy Tissue Remodeling and Formation. By aiding collagen synthesis, PureWay-C^® supports the development and repair of body tissues. This encourages healthy tissue formation during healing periods or after stress from exercise.²²

  
  

• Supports Joint Mobility. PureWay-C^® helps repair and maintain connective tissue, which supports optimal joint recovery and longevity.²³

  
  

• Bolsters Joint Recovery. PureWay-C^® helps improve recovery outcomes after joint stress, supporting tissue repair processes and joint integrity.²⁴

  
  

• Provides Antioxidant Protection. Thanks to its high bioavailability, PureWay-C^® offers superior antioxidant support, helping to combat oxidative stress and maintain connective tissue resilience.²⁵

Remodel Clinic™ contains 90 mg of PureWay-C^®.

Studies show supplementing with Collagen Type II helps:

• Reduce exercise-related joint pain and stiffness (in healthy subjects)³⁷

• Provide joint cushioning and lubrication⁸⁰

• Prevent collagen degradation from overuse⁷⁸

And when you take Type II collagen in its natural form, it produces a unique benefit that other collagen supplements simply can't offer.

A recent study published in HealthMED found that supplementing with 750 mg of a natural collagen matrix containing collagen Type I, II, V, and X can help stimulate collagen synthesis, specifically within cartilage tissues.⁸⁰

Joint Clinic™ contains 750 mg of a patented natural collagen matrix called Balanced Kollagen^® (made of 50% Type II Collagen).

This traditional Ayurvedic herb has long been revered as the “bone setter” plant.  It's used in traditional medicine to aid the healing process after bone or soft tissue damage.⁵

Though many of the citations for Cissus quadrangularis that promote it as a joint-healing aid used a topical (applied directly to the skin) preparation made from the raw stems and leaves, studies show oral consumption of Cissus extract also has the ability to shorten recovery times and improve mobility after physical stress to a joint.^{18, 74}

And it’s one of the few herbs proven to improve joint function in athletes.¹

When you look at the breadth of research across human trials, animal studies, traditional use history, and mechanism of action studies. It’s clear that Cissus is one of the most proven natural solutions for joint recovery.

Research shows Cissus helps:

• Stimulate osteoblast production for healthy bone mineralization and joint strength^{6, 10}

• Reduce joint soreness from exercise (3,200 mg reduced joint pain by 31% in 8 weeks)¹

• Support healthy inflammation levels from exercise¹⁴

• Reduce oxidative stress via antioxidant activity^{15, 16}

The clinically supported dosage for improving joint health in humans is 3,200 mg at 2.5% standardization of active ketosterones. 

Joint Clinic™ contains 1,600 mg of Cissus quadrangularis at 5% concentration.

This dosage mirrors the active component concentration used in the most relevant study on joint health in athletes while still enabling us to get the ingredients into a practical serving size.

With over 100 publications and more than 45 human clinical studies, Curcumin C3 Complex^® is the most scientifically-backed turmeric in the world.

Research shows supplementing with C3 Complex:

• Promotes collagen formation after physical stress^{21, 22}

• Improves subjective pain levels by 40%^{71, 26}

• Supports healthy inflammation levels (specifically within osteocartilaginous tissue)²⁶

• Improves joint stiffness and mobility by 86% in 6 weeks²⁴

• Reduces oxidative stress via antioxidant effects²³

The most common clinically supported dosages of C3 for joint health range from 200 mg to 1,500 mg.

Joint Clinic™ contains 1,000 mg of Curcumin C3 Complex^® Turmeric Extract per serving.

Hyaluronic acid is a natural substance in the human body with its highest concentrations in the joint structures and eyes.  It’s a major component of synovial fluid, the body’s natural joint lubricant.

Studies show supplementing with hyaluronic acid:

• Improves synovial fluid effusion in joints and reduces joint discomfort³⁸

• Improves joint strength (52 mg of hyaluronic acid helped healthy subjects with mild joint discomfort improve their knee strength)³⁹

Clinically supported dosages of hyaluronic acid range from 40 mg to 80 mg.

Joint Clinic™ contains ~60 mg of hyaluronic acid per serving from Balanced Kollagen^®.

CoQ10 is a compound that helps generate energy in cells and enhances blood flow. Production of CoQ10 decreases with age, which makes it a popular supplement for heart health and longevity. 

Though you may be surprised to see CoQ10 in a joint recovery formula, it’s a well-studied compound for exercise-induced stress.

Studies show supplementing with CoQ10:

• Reduces exercise-related damage and oxidativestress^{34, 35}

• Supports healthy post-exercise inflammation levels³⁶

Commonly used clinically supported dosages range from 90 mg to 200 mg, with only small increases in efficacy at higher dosages.

Joint Clinic™ contains 90 mg of CoQ10.

Grape seed extract is well-known for its ability to support overall cardiovascular health and circulation — an important process for nutrient delivery to recovering tissues. But grape seed also aids the recovery process in three other important ways.

Research shows grape seed extract:

• Supports cartilage health after exposure to physical stress²⁷

• Reduces total body oxidation via antioxidant effects²⁸

• Helps maintain healthy inflammation levels²⁹

Grape seed also appears to work synergistically with olive leaf extract (also in this formula) to support joint recovery after exposure to physical stress.³⁰

Clinically supported dosages of grape seed extract range from 150 mg to 300 mg daily.

Joint Clinic™ contains 300 mg of grape seed extract per serving.

A study published in the journal Nutrients found that supplementing with 50 mg of olive extract improved age-related joint pain and stiffness in as little as 4 weeks.³¹

Research shows supplementing with olive leaf extract:

• Helps maintain healthy cartilage levels after exposure to physical stress³⁰

• Supports glutathione levels in healthy subjects, which helps supports total body immune health³²

• Supports healthy inflammation levels via oleuropein³³

Clinically supported dosages of olive extract supplements vary widely. They are highly dependent on the standardization of specific compounds such as hydroxytyrosol and oleuropein.

Joint Clinic™ contains 100 mg of olive leaf extract standardized to 20% oleuropein.

BioPerine^® is a patented extract of black pepper that contains 95% piperine. Piperine is the alkaloid responsible for the spice of black pepper. It has been used in traditional medicine to aid digestion and nutrient bioavailability.

Modern science has confirmed what traditional wisdom passed down. Studies show black pepper increases hydrochloric acid and levels of enzymes that help break down food into digestible components.⁴⁰

As mentioned above, BioPerine^® is proven to enhance the absorption of turmeric by 2,000% (20X). Clinically supported dosages of BioPerine^® range from 2 mg to 20 mg.

Joint Clinic™ contains 10 mg of BioPerine^® per serving.

While taking a multivitamin is likely better than taking nothing, studies show that taking higher dosages of specific vitamins and minerals during the first few weeks of a recovery period has advantages.^{42, 43}

So instead of throwing a blanket list of vitamins A-Z into Joint Clinic™, we used only the most crucial nutrients for joint and connective tissue recovery.

That includes clinically-supported dosages of vitamins A, C, D3, and K2. Plus chromium, magnesium, manganese, selenium, and zinc.

1. https://www.oarsijournal.com/article/S1063-4584(07)61727-0/abstract

2. https://www.ncbi.nlm.nih.gov/pubmed/21251991

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950747

4. https://www.ncbi.nlm.nih.gov/pubmed/28177710

5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793325/

6. https://www.mdpi.com/2072-6643/11/5/1154/htm

7. https://www.mdpi.com/2072-6643/11/4/892/htm

8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/

9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246064/

10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204628/

11. https://www.ncbi.nlm.nih.gov/pubmed/16685547

12. https://www.ncbi.nlm.nih.gov/pubmed/30859848

13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691677/

14. https://www.nature.com/articles/srep33527

15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227229/

16. https://pubmed.ncbi.nlm.nih.gov/20308995/

17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938278/

18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546016/

19. https://pubmed.ncbi.nlm.nih.gov/20308995/