This traditional Ayurvedic herb has long been revered as the “bone setter” plant.  It's used in traditional medicine to aid the healing process after bone or soft tissue damage.⁵

Though many of the citations for Cissus quadrangularis that promote it as a joint-healing aid used a topical (applied directly to the skin) preparation made from the raw stems and leaves, studies show oral consumption of Cissus extract also has the ability to shorten recovery times and improve mobility after physical stress to a joint.^{18, 74}

And it’s one of the few herbs proven to improve joint function in athletes.¹

When you look at the breadth of research across human trials, animal studies, traditional use history, and mechanism of action studies... It’s clear that Cissus is one of the most proven natural solutions for joint recovery.

Research shows Cissus helps:

• Stimulate osteoblast production for healthy bone mineralization and joint strength^{6, 10}
• Reduce joint soreness from exercise (3,200 mg reduced joint pain by 31% in 8 weeks)¹
• Support healthy inflammation levels¹⁴
• Reduce oxidative stress via antioxidant activity^{15, 16}

The clinically supported dosage for improving joint health in humans is 3,200 mg at 2.5% standardization of active ketosterones. 

Joint Clinic contains 1,600 mg of Cissus quadrangularis at 5% concentration.

This dosage mirrors the active component concentration used in the most relevant study on joint health in athletes while still enabling us to get the ingredients into a practical serving size.

With over 100 publications and more than 45 human clinical studies, Curcumin C3 Complex^® is the most scientifically-backed turmeric in the world.

Research shows supplementing with C3 Complex:

• Promotes collagen formation after physical stress^{21, 22}
• Improves subjective pain levels by 40%^{71, 26}
• Supports healthy inflammation levels (specifically within osteocartilaginous tissue)²⁶
• Improves joint stiffness and mobility by 86% in 6 weeks²⁴
• Reduces oxidative stress via antioxidant effects²³

The most common clinically supported dosages of C3 for joint health range from 200 mg to 1,500 mg.

Joint Clinic contains 1,000 mg of Curcumin C3 Complex^® Turmeric Extract per serving.

Hyaluronic acid is a natural substance in the human body with its highest concentrations in the joint structures and eyes.  It’s a major component of synovial fluid, the body’s natural joint lubricant.

Studies show supplementing with hyaluronic acid:

• Improves synovial fluid effusion in joints and reduces joint discomfort³⁸
• Improves joint strength (52 mg of hyaluronic acid helped healthy subjects with mild joint discomfort improve their knee strength)³⁹

Clinically supported dosages of hyaluronic acid range from 40 mg to 80 mg.

Joint Clinic contains ~60 mg of hyaluronic acid per serving from Balanced Kollagen^®.

CoQ10 is a compound that helps generate energy in cells and enhances blood flow. Production of CoQ10 decreases with age, which makes it a popular supplement for heart health and longevity. 

Though you may be surprised to see CoQ10 in a joint recovery formula, it’s a well-studied compound for exercise-induced stress.

Studies show supplementing with CoQ10:

• Reduces exercise-related damage and oxidativestress^{34, 35}
• Supports healthy post-exercise inflammation levels³⁶

Commonly used clinically supported dosages range from 90 mg to 200 mg, with only small increases in efficacy at higher dosages.

Joint Clinic contains 90 mg of CoQ10.

Grape seed extract is well-known for its ability to support overall cardiovascular health and circulation — an important process for nutrient delivery to recovering tissues. But grape seed also aids the recovery process in three other important ways.

Research shows grape seed extract:

• Supports cartilage health after exposure to physical stress²⁷
• Reduces total body oxidation via antioxidant effects²⁸
• Helps maintain healthy inflammation levels²⁹

Grape seed also appears to work synergistically with olive leaf extract (also in this formula) to support joint recovery after exposure to physical stress.³⁰

Clinically supported dosages of grape seed extract range from 150 mg to 300 mg daily.

Joint Clinic contains 300 mg of grape seed extract per serving.

A study published in the journal Nutrients found that supplementing with 50 mg of olive extract improved age-related joint pain and stiffness in as little as 4 weeks.³¹

Research shows supplementing with olive leaf extract:

• Helps maintain healthy cartilage levels after exposure to physical stress³⁰
• Supports glutathione levels in healthy subjects, which helps supports total body immune health³²
• Supports healthy inflammation levels via oleuropein³³

Clinically supported dosages of olive extract supplements vary widely. They are highly dependent on the standardization of specific compounds such as hydroxytyrosol and oleuropein.

Joint Clinic contains 100 mg of olive leaf extract standardized to 20% oleuropein.

BioPerine^® is a patented extract of black pepper that contains 95% piperine. Piperine is the alkaloid responsible for the spice of black pepper. It has been used in traditional medicine to aid digestion and nutrient bioavailability.

Modern science has confirmed what traditional wisdom passed down. Studies show black pepper increases hydrochloric acid and levels of enzymes that help break down food into digestible components.⁴⁰

As mentioned above, BioPerine^® is proven to enhance the absorption of turmeric by 2,000% (20X). Clinically supported dosages of BioPerine^® range from 2 mg to 20 mg.

Joint Clinic contains 10 mg of BioPerine^® per serving.

While taking a multivitamin is likely better than taking nothing, studies show that taking higher dosages of specific vitamins and minerals during the first few weeks of a recovery period has advantages.^{42, 43}

So instead of throwing a blanket list of vitamins A-Z into Joint Clinic, we used only the most crucial nutrients for joint and connective tissue recovery.

That includes clinically-supported dosages of vitamins A, C, D3, and K2. Plus chromium, magnesium, manganese, selenium, and zinc.